DSIP
A peptide first found in rabbits that seemed to promote deep sleep. Human results have been inconsistent, and its natural role is still unclear.
- Evidence
- Limited human research
- Half-life
- Minutes
- Sources
- 2 cited
Is DSIP FDA-approved?
Not approved by the FDA. Products sold online as "research chemicals" aren't checked for purity, sterility or dose.
Overview
DSIP was isolated in the 1970s from the blood of sleeping rabbits. Small human studies in the 1980s and 1990s gave mixed results: one double-blind study in people with chronic insomnia found slightly better sleep efficiency, but the effect was small. Decades later, scientists still haven't found a gene or receptor for it.
How it works
Unclear. It may influence stress-hormone and sleep-regulating systems in the brain, but no specific receptor has been identified.
How long does DSIP stay in the body?
Minutes in the blood.
What it's studied for
- Insomnia
- Stress hormones
- Withdrawal symptoms
Related: Larazotide, Melanotan II, Thymalin, VIP (Vasoactive Intestinal Peptide).
Sources
The studies and prescribing labels this page is written from.
- Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem, 2006 PubMed
- Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients: a double-blind study. Neuropsychobiology, 1992 PubMed
