Dihexa
An experimental compound derived from angiotensin IV that improved memory in rats and mice. No human trials.
- Evidence
- Primarily preclinical research
- Half-life
- Not known
- Sources
- 2 cited
Is dihexa FDA-approved?
Not approved by the FDA. Products sold online as "research chemicals" aren't checked for purity, sterility or dose.
Overview
Dihexa was designed at Washington State University to boost the HGF/c-Met system, which helps neurons form new connections. In rodents it improved memory and reversed deficits in Alzheimer's-type models. There are no published human studies. Because the HGF/c-Met pathway also drives some cancers, researchers have raised long-term safety questions.
How it works
It helps HGF switch on its receptor, c-Met, which promotes new synapses between brain cells.
How long does dihexa stay in the body?
Not established in people.
What it's studied for
- Memory (rodents)
- Alzheimer's and Parkinson's models
Related: Cerebrolysin, Pinealon, Selank, Epitalon.
Sources
The studies and prescribing labels this page is written from.
- Procognitive and synaptogenic effects of angiotensin IV-derived peptides depend on HGF/c-Met. J Pharmacol Exp Ther, 2014 PubMed
- Small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases. Prog Neurobiol, 2015 PubMed
